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, Joachim H Ix Division of Preventive Medicine, Department of Family and Preventive Medicine, University of California San Diego, San Diego, California, USA Division of Nephrology, Department of Medicine, University of California San Diego, and Veterans Affairs San Diego Healthcare System, San Diego, California, USA Search for other works by this author on: Oxford Academic Christina L Wassel Department of Medicine and Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA Department of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA Search for other works by this author on: Oxford Academic Douglas C Bauer Department of Medicine and Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA Search for other works by this author on: Oxford Academic Damon Toroian Division of Biological Sciences, University of California San Diego, San Diego, California, USA Search for other works by this author on: Oxford Academic Frances A Tylavsky Department of Preventive Medicine, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA Search for other works by this author on: Oxford Academic Jane A Cauley Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA Search for other works by this author on: Oxford Academic Tamara B Harris Laboratory for Epidemiology, Demography, and Biometry, National Institutes of Aging, Bethesda, Maryland, USA Search for other works by this author on: Oxford Academic Paul A Price Division of Biological Sciences, University of California San Diego, San Diego, California, USA Search for other works by this author on: Oxford Academic Steven R Cummings San Francisco Coordinating Center, San Francisco, California, USA Department of Medicine, California Pacific Medical Center, San Francisco, California, USA Search for other works by this author on: Oxford Academic Michael G Shlipak General Medicine Section, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA Department of Medicine and Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA Search for other works by this author on: Oxford Academic
Journal of Bone and Mineral Research, Volume 24, Issue 3, 1 March 2009, Pages 514–521, https://doi.org/10.1359/jbmr.081017
Published:
04 December 2009
Article history
Received:
11 June 2008
Revision received:
25 September 2008
Accepted:
09 October 2008
Published:
04 December 2009
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Joachim H Ix, Christina L Wassel, Douglas C Bauer, Damon Toroian, Frances A Tylavsky, Jane A Cauley, Tamara B Harris, Paul A Price, Steven R Cummings, Michael G Shlipak, Fetuin‐A and BMD in Older Persons: The Health Aging and Body Composition (Health ABC) Study, Journal of Bone and Mineral Research, Volume 24, Issue 3, 1 March 2009, Pages 514–521, https://doi.org/10.1359/jbmr.081017
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Abstract
Fetuin‐A is a hepatic secretory protein that promotes bone mineralization in vitro. Whether fetuin‐A levels are associated with BMD in humans is unknown. The Health Aging and Body Composition study enrolled 3075 well‐functioning black and white persons 70–79 yr of age and measured BMD. This cross‐sectional study measured serum fetuin‐A using ELISA among a random sample of 508 participants within sex and race strata. Multivariate linear regression analysis evaluated the associations of fetuin‐A with BMD. Among women (n = 257), higher fetuin‐A levels were significantly associated with higher total hip (p = 0.02), lumbar spine (p = 0.03), and whole body BMD (p = 0.01) in models adjusted for age, race, diabetes, alcohol and tobacco use, physical activity, body mass index, C‐reactive protein levels, calcium supplement, and estrogen use. For example, each SD (0.38 g/liter) higher level of fetuin‐A was associated with 0.016 g/cm2 higher total hip areal BMD. The association was of similar magnitude and direction for femoral neck BMD but did not reach statistical significance (p = 0.11). In contrast, among men (n = 251), fetuin‐A had no significant associations with total hip (p = 0.79), lumbar spine (p = 0.35), whole body (p = 0.46), or femoral neck BMD (p = 0.54) in multivariable models. We conclude that higher fetuin‐A levels are independently associated with higher BMD among well‐functioning community‐dwelling older women but not older men. Future studies should evaluate whether fetuin‐A may refine fracture risk assessment in older women.
fetuin‐A, BMD, elderly
Copyright © 2009 ASBMR
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
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